Some infants with caudal regression syndrome may have a genetic predisposition to creating the disorder. Researchers consider that both environmental and genetic elements might play a task in the improvement of the disorder. Most instances appear to happen randomly for no obvious cause , which suggests environmental factors or a model new gene mutation. Most likely, caudal regression syndrome is multifactorial, which signifies that a number of various factors could play a causative role. In addition, completely different genetic factors could contribute to the disorder in several individuals .