Inflammation in these joints might not reply to NSAIDs alone. For these people, the addition of disease-modifying antirheumatic drugs that suppress the physique’s immune system is considered. These drugs, such assulfasalazine , might result in long-term discount of inflammation. An various to sulfasalazine that is considerably simpler is methotrexate , which could be administered orally or by injection. Ankylosing spondylitis is 2 to 3 times extra frequent in males than in women. In women, joints away from the spine are more regularly affected than in males.