Tofacitinib is an immunosuppressive treatment presently approved to deal with rheumatoid arthritis and different situations. Currently, tofacitinib is underneath investigation for the treatment of ankylosing spondylitis. Life expectancy for ankylosing spondylitis is identical as the final population, besides in these with very extreme illness. Ankylosing spondylitis patients with the most severe type of disease, or who develop sure complications, can have a shortened life expectancy. Finally, orthopedic surgical procedure could additionally be required when there is extreme illness of the hip joints and spine.