The relationship between infectious brokers and the triggering of chronic irritation is vigorously being pursued. Factors that perpetuate “autoimmunity” are being recognized. The characteristics of the gene marker HLA-B27 are being further outlined. In fact, there are actually known to be seven totally different subtypes of HLA-B27. Prevention measures are directed toward stopping issues of the disease with optimum remedies and monitoring for side effects of the remedies. Magnetic resonance imaging can also be carried out to assess the diploma of sure anomalies similar to spinal defects.